This presentation offers a detailed case study of a collaborative initiative between Integrated Containment Systems (ICS) and University of Iowa Pharmaceuticals (UIP) to design and implement a next-generation aseptic and toxic fill-finish system. The project was driven by the need for a flexible, high-throughput solution capable of handling potent compounds while maintaining strict aseptic conditions and regulatory compliance.

The system integrates isolator-based technology with advanced automation, including ISO 5 environments, guillotine doors, RTPs, and conveyor systems. It features cascading pressure zones and HEPA filtration to ensure both product sterility and operator safety. The presentation will walk attendees through the full lifecycle of the project—from concept and design to qualification and operation—highlighting key innovations and lessons learned.

Attendees will gain practical insights into:

Customizing isolator systems for multi-product aseptic fill-finish operations
Implementing automated material handling and transfer systems
Maintaining chain of custody and environmental control in toxic fill scenarios
Navigating facility constraints and real-estate limitations with modular design

This session is ideal for professionals seeking actionable strategies to modernize aseptic manufacturing facilities and meet the demands of increasingly complex pharmaceutical production environments.

George Andrew Pyck

Sr VP of Technical Sales, Custom Powder Systems

Appearances