The presentation provides a general definition of the fourth industrial revolution by using 4 pillars of Industry 4.0 as reference: Things, Connectivity, Data and Analytics. Modern system architecture transition from complex parallel wiring to digital solutions is described, and advantages of such improvement are shown in details. Secure measures to enable machine remote connections and ensure data integrity and redundancy are highlighted. Advanced data analytics procedures with real case example are shown, including a description of the advantages related to improved machine performance and maintenance. A new tool for retrospective process analysis is also presented. As a result of this presentation, attendees will understand how digitalization of a machine can enable GMP relevant advantages; improve data integrity; and enhance operators training procedures.