Building new facilities can take years. We want to run the plants for decades. Supply plans changes after completing the facilities’ designs result in changes for processes to be run in the facilities. Flexibility to address potential future company needs requires facility reconfigurability. In this presentation, reconfigurable design options will cover how facilities might have capabilities for a combination of: high titer monoclonal antibody production with perfusion cell culture, low titer monoclonal antibody production with fed batch cell culture, mRNA processing, semi-continuous purification, and batch purification. We will also discuss best practice to advance Digital 4.0 with lessons learned, as many companies are advancing digital strategies for new and existing facilities. Finally, environmentally sustainable designs and designs for Employee Wellness are key to make the world a better place and attract talent: Sometimes there is synergy in the programs. In a few instances the two scorings compete against each other a little. We will discuss some recent lessons.