Supply chain end-to-end lead times are typically long, triggering decision-making prior to the actual customer demand signals. Demand can be highly variable and unpredictable, while the industry is often challenged with drug shortages. As political, regulatory, and market demand requirements evolve, one’s ability to respond appropriately and in a timely fashion is therefore undermined. Today’s manufacturing platforms and associated analytics are smaller, lighter, and significantly more modular versus their predecessors, enabling much smaller factory footprints, allowing for the realization of a transportable manufacturing platform and facilities concept. These flexible, transportable units can address variable demand through scale out (running the continuous process longer, or replication of the unit), and may be installed more quickly than traditional manufacturing site expansion. Consequently, when business needs change down the road, the manufacturing unit can be moved to another location. The potential financial, technical, and regulatory obstacles for the movability of a manufacturing environment will be addressed. Case studies will be presented that illustrate the benefits of mobility and the opportunities and challenges of operating a mobile facility.