For Engineering & Operations teams, the pandemic posed an unprecedented set of challenges. Without a playbook, groups had to respond to new imperatives with a completely unique set of constraints. Everything had to be reimagined. This also provided an opportunity to redefine business processes, ways of working and engineering constructs that had been in place for a while, by creating a platform for accelerating transformations in spaces that till date were viewed as emerging (e.g., digital, sustainability and ESG, hybrid workspaces). This presentation takes a step back and reflects upon lessons learned from a practitioner viewpoint, focusing on how the Engineering, Facilities, and Operations teams within the industry responded to a crisis. The presentation leverages at-scale examples within Gilead Sciences’ operations efforts to highlight trends that we believe will become future standards, and areas that require our industry to continue innovating.