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Process intensification and continuous manufacturing have generated a lot of interest within pharmaceutical industry to bring therapies faster to market, increase productivity and make the most efficient use of production assets. This presentation will provide an overview of the business drivers that led to drug product continuous manufacturing at Vertex. Included will be considerations for developing process and control strategy, review of anticipated hurdles, surmountable challenges, and the unforeseen organizational benefits of implementing continuous manufacturing. In addition, general considerations for maximizing the operational efficiency of continuous manufacturing will be discussed.