Assets experience infancy. Assets experience adolescence. Assets experience mid-life (crisis). Assets experience maturity. And, in all cases, assets will experience end-of-life. At Johnson & Johnson (JNJ), assets experience the full lifecycle of performing in an FDA regulated environment under the watchful eye of Manufacturing Equipment Excellence (ME2). For 20 years, the ME2 program at J&J has driven excellence into everything related to manufacturing assets, including advanced technologies. Today, the technological elements of Asset Performance Management (APM) are ever present in JNJ's ongoing ME2 efforts to continuously improve and re-invent what's considered "good". Tried and true processes including Reliability Centered Maintenance (RCM), Total Productive Maintenance (TPM) are put to the test, year in and year out, plus technologies like Asset Lifecycle Information Management (ALIM) and Enterprise Asset Management (EAM) continue to converge and analyze asset data in more meaningful ways. Today, ME2 is considered the global milestone of manufacturing asset management within the life sciences.