Supply chain disruptions remain a challenge across industries, while at the same time, speed to market and greater accessibility to quality medicines has become an even greater business imperative. Digital technologies are widely available for pharma manufacturing and are key to the industry overcoming these hurdles and progressing the Pharma 4.0 vision. The need for continuous improvement comes with the territory and reinforces the reality that digital transformation is never truly complete. By adopting a range of technologies that address what might seem like discrete challenges (unplanned downtime, cumbersome batch review, reactive instead of proactive planning and scheduling), a company can build its resiliency across the value chain network. The whole is then greater than the sum of its parts.