This presentation will show that the pharmaceutical industry is operating in a highly regulated environment. It will elaborate on opportunities for a holistic control of distribution, which will need a multi-stakeholder approach in the supply chain. Doing so, it will be explaining the risks limiting availability and potential drivers of shortages based on a diversity of hazards. Opportunities are presented how every stakeholder can reduce the risk for shortages. The bases for this is the need for an understanding for the role and responsibilities. The presentation concludes with examples on drug shortage prevention strategies and includes best practices.