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This keynote address will provide insights into some of the initiatives taken by the Office of Quality Surveillance (OQS) within the Office of Pharmaceutical Quality (OPQ), on enhancing an overall proactive quality surveillance framework through the integration of advanced analytics for assessing Pharmaceutical Quality System (PQS) effectiveness, Post-Market Quality Signal Detection, Quality Metrics (QM), and Quality Management Maturity (QMM), covering the latest program updates and implementations for advancing and modernizing quality surveillance.