EMA's Role in Protecting Public Health in Times of Crisis| The experience of the COVID pandemic showed that a reinforced framework to strengthen structures and mechanisms can ensure better EU level protection, prevention, preparedness and response in crisis situations. Coordination and cooperation between Member States and Third Country Authorities is crucial. EMA’s activities to tackle shortages, scientific review and coordination of clinical trials, as well as alternative tools for the GMP verification of facilities provided us with valuable lessons. Europe’s regulatory response to the pandemic is a success story. How can we build on this to prepare and prevent future crises?