Blockchain and Smart Pharmaceutical Manufacturing | In recent decades, the pharmaceutical sector has emerged as a pioneer of integrated production. Currently, the world is advancing towards a more secure and integrated industrial revolution 4.0, aided by technologies such as the Internet of Things (IoT), Internet of Services (IoS), and cloud computing. These services are enablers or what we term smart manufacturing domains or best practices for improving productivity and speeding up the manufacturing process. However, there are several hurdles to smart manufacturing or industry 4.0, such as: - Data security - Traceability, and - The trust that current industrial complexes lack. In this case, blockchain becomes a critical component of smart manufacturing. As the riddle of blockchain has captured the whole globe, it has begun to present itself as a superior alternative to the existing integration system and security. This is a significant step towards the future of smart, automated, and self-driving production. However, there are several problems and possibilities in smart manufacturing.