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In this presentation Dr. O'Connell will present an introduction to the twin concepts of Lean Manufacturing and the Six Sigma Quality improvement strategy, DMAIC, ending with describing how they can be jointly applied to pharmaceutical manufacturing. The term LSS or Lean Six Sigma is currently used in a number of successful manufacturing companies (both worldwide and in Ireland). This presentation will describe the various forms of non-value add in manufacturing, highlight the benefits, phases of DMAIC and give an overview accompanying tools used for process improvement, specifically the reduction of variability. Lean will focus on enhancing throughput as it involves the elimination of non-value add activities in the manufacturing process.