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Downstream Process Development for High Productivity Purification of Plasmid DNA

‐ Jun 27, 2023 4:50pm

Key challenges in pDNA manufacturing exist around purification unit operations due to its large size, high viscosity, shear sensitivity, and similarities between pDNA and impurities. During this presentation a generic manufacturing template that overcomes these challenges will be discussed based on a comprehensive case study encompassing all downstream unit operations (operations include cell harvest, lysis, clarification, tangential flow filtration, and chromatography).


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