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In an era where the need for groundbreaking treatments to address unmet medical needs has never been more pressing, it is crucial for us in the pharmaceutical engineering community to develop and enable technologies in a timely manner. In this keynote, Judy Chou, Ph.D., President and Chief Executive Officer of AltruBio will address the successful introduction of novel therapies, especially Advanced Therapeutic Medical Products (ATMPs), as a testament to the fruitful partnership between engineers and biological scientists. To accelerate the development of novel therapeutics further, significant opportunities for enhancement remain, particularly in the realms of operational excellence in manufacturing and addressing sustainability challenges related to supply chains and energy consumption. Embracing ongoing disruptive technologies is imperative and inevitable in achieving these goals.